By Giancarlo Lancini, Francesco Parenti, Gian Gualberto Gallo (auth.)
In this translation of the Italian moment version, the authors offer a finished account of the present wisdom on antibiotics. They concisely describe how a number of medical disciplines are inquisitive about antibiotics learn, improvement, and use. Their paintings additionally discusses the economic and scientific improvement of recent antibiotics, in addition to the questions and controversies with regards to the functionality of antibiotics in nature. Antibiotics is richly illustrated with transparent chemical constructions, drawings, diagrams, and synoptical tables.
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Extra resources for Antibiotics: A Multidisciplinary Approach
Enter the cell and reach the site of action 2. Bind physically to a cellular structure (target molecule) involved in a process essential for maintenance of cell growth or homeostasis, and 3. Markedly inhibit this process At the cellular Ievel, as already described in Chapter 2, an antibiotic can be bactericidal or bacteriostatic. The bactericidal effect may result from either of two mechanisms: 1. The antibiotic interaction with its target molecule induces an irreversible disruption of the cell integrity or functions.
3. Inhibitors of Cell Wall Synthesis* Before discussing the mechanisms of action of inhibitors of cell wall synthesis, we shall briefly describe the chemical structures of the cell wall of different microorganisms and the pathways through which the main components are synthesized. 1. Structure and Architecture of the Cell Wall The cell wall is a rigid structure that envelopes the microbial cell, determines its shape, and protects it from bursting as a consequence of the high intemal osmotic pressure.
A given organism may contain four to eight PBPs, with molecular weights from 35,000 to 120,000. When a "novel" PBP is identified in an organism, it is numbered as a derivative of the established ones. For instance, the novel 78,000-Mr PBP found in methicillin-resistant S. aureus (in addition to the existing PBP-2 of 80,000 Mr) has been designated as PBP-2a (or PBP-2'). PBPs essential for cell growth normally have transpeptidase activity. These control the fundamental processes of cell elongation and division, and usually have a high molecular weight (60,000 to 120,000 Mr).
Antibiotics: A Multidisciplinary Approach by Giancarlo Lancini, Francesco Parenti, Gian Gualberto Gallo (auth.)