New PDF release: Apoptosis, Cell Signaling, and Human Diseases: Molecular

By Rakesh Srivastava

ISBN-10: 1588296776

ISBN-13: 9781588296771

ISBN-10: 1588298825

ISBN-13: 9781588298829

ISBN-10: 1597451991

ISBN-13: 9781597451994

(for either volumes) Apoptosis, phone Signaling, and Human ailments: Molecular Mechanisms, Volumes 1 & 2, current a concise synthesis of modern advancements within the knowing of either telephone survival and apoptotic pathways. specific awareness is given to apoptosis in human illnesses, resembling varied kinds of melanoma and neurodegenerative illnesses. those entire volumes combine the main leading edge and present findings from a number of similar disciplines of clinical study, together with pathology, genetics, virology, cellphone biology, immunology, and molecular biology. quantity 1 is split into sections: "Malignant Transformation and Metastasis" and "Molecular foundation of disorder Therapy." quantity 2 follows an identical constitution and is split into sections entitled "Kinases and Phosphate" and "Molecular foundation of telephone Death." the entire participants are on the leading edge of clinical discovery, and the reports they current systemically learn the main interesting and leading edge points in their specific parts of craftsmanship. Researchers will locate those volumes of significant profit as they look for novel and greater remedies for human illnesses.

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Extra info for Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms

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J Biol Chem 1993;268:5774–5782. 122. Harada H, Becknell B, Wilm M, et al. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell 1999;3:413–422. 28 Nesterova and Cho-Chung 123. Pinto A, Aldinucci D, Gattel V, et al. Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukemia patients by site-selective 8-chloroadenosine 3e,5e-cyclic monophosphate. Proc Natl Acad Sci USA 1992;89:8884–8888. 124. Tortora G, Ciardiello F, Pepe S, et al.

In particular, protein kinase cascades are emerging as important modulators of the apoptotic response (17). These include the phosphoinositide 3-kinase/AKT (PI3-kinase/AKT) pathway, the c-Jun-N-terminalKinase (JNK) and p38 pathways, the Janus-Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway (18–20), and many isoforms of PKC. Activation of these cascades can result in direct phosphorylation of apoptotic proteins, or regulate apoptosis by activating or inhibiting the transcription of pro- or anti-apoptotic genes.

8. Corbin JD, Keely SL, Park CR. The distribution and dissociation of cyclic adenosine 3e,5emonophosphate-dependent protein kinases in adipose, cardiac, and other tissues. J Biol Chem 1975;250:218–225. 9. Lee DC, Carmichael DF, Krebs EG, McKnight GS. Isolation of a cDNA clone for the type I regulatory subunit of bovine cAMP-dependent protein kinase. Proc Natl Acad Sci USA 1983;80:3608–3612. 10. Sandberg M, Tasken K, Oyen O, Hansson V, Jahnsen T. Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis.

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Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms by Rakesh Srivastava

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